Skin pigmentation
research & testing platform
R&D solutions for pigmentation research
In order to open new horizons for scientific research in the field of pigmentation and more specifically for the testing and screening of active dermo-cosmetic ingredients, Phenocell has developed a new & exclusive human melanocyte model based on induced pluripotent stem cells (iPSC).
iPSC-derived melanocytes display all the key functional characteristics of normal human melanocytes, including melanin synthesis, while having - unlike immortalized melanocytes - a normal karyotype. Due to their high genomic stability, their availability in unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are the most robust and relevant tool for the execution of your screening campaigns and R&D projects.
Identify and characterize new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived melanocytes!
Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells:
-
high genomic stability
-
available in unlimited quantities
-
high batch-to-batch reproducibility
iPSC-derived cells are the most relevant model for HTS studies on human cells!
Your iPSC-derived melanocyte screening campaign
Starting from
4500€/96wp
High-throughput screening services for
pigmentation research & testing
An in vitro melanocyte model
close to reality
Biodiversity
Phenocell's pigmentation model is based on the use of iPCS-derived melanocytes from multiple donors:
-
Human iPSC-melanocytes from asian donors
- Human iPSC-melanocytes from african donors
-
Human iPSC-melanocytes from caucasian donors
-
Human iPSC-melanocytes from albino donors
Useful for ethnicity-specific claim validation
Cell culture format
Phenocell's iPCS-derived melanocytes model is available:
-
in monolayers (from 6 wp down to 96 wp)
Cell characterization
Phenocell's iPCS-derived melanocyte are fully characterized:
-
Normal karyotype
-
High level of purity (>90%)
-
Expression of key melanocyte markers
(e.g. PAX3, MITF, PMEL17, TRYP1) -
Melanin synthesis
-
Melanosome transfer to keratinocytes
Cell functionality
Phenocell's iPSC-derived melanocyte are useful and validated for testing:
-
Cell toxicity & cell survival
-
Oxydative stress
-
Melanongenesis related markers (e.g. Pmel17, TYR, TRYP1, MITF)
-
Melanin synthesis (pro and anti-pigmentating effect)
Get a sample report on
iPSC-derived melanocyte model
Melanogenesis-related bioassays
Bellow are examples of pigmentation-related bioassays that Phenocell offers as service :
If you do not find your favorite bioassays, do not worry,
Custom biological tests are available.
Contact us for more information.
1
2
3
4
Management of your R&D project
Preliminary study
NDA
Project framework
Feasibility study
Quotation
Service agreement, order
Experiment
Compound receipt
iPSC culture
Testing & Bioassays
Data management
Quality control
Data analysis
Data minding
Report
Report writing
Report meeting
Get in touch with our team for any questions or inquiries. You can reach out by emailing operations@axolbio.com or clicking the button below.
