Neural Progenitor Cells

Highly proliferative neural progenitor cells, available in 1M cell format and optimized culture medium.

Neural Progenitor Cells (NPC) functions & facts

Neural Progenitor Cells are multipotent cells of the ectoderm lineage. They can differentiate into three central nervous system (CNS) cells, neurons, astrocytes and oligodendrocytes :

- Sensory or afferent neurons convert a specific stimulus (smell, taste, vision, audition, temperature, pressure, pain) via their receptor into action potentials.
- Motorneurons are divided into two classes, upper and lower. Upper motor neurons link the cerebral cortex to the spinal cord, while lower motor neurons link the spinal cord to multiple muscle fibres or glands. They control every voluntary or involuntary movements in our body.
- Interneurons also called connector neurons may link two brain regions or afferent and efferent neurons by providing neural circuit.
- Oligodendrocytes synthetize the myelin sheath surrounding the axons of the CNS, which increases the electric signal speed.
- Astrocytes have many functions. They support the blood-brain barrier, handle nutriments supply, detoxify and repair the brain.

NPC are characterized by their morphology, gene expression profile, temporal distribution, function and location. In the adult brain, NPC are observed in the sub granular zone within the dentate gyrus of the hippocampus or the sub ventricular zone of the lateral ventricles [1].

They have two types of cell division : symmetric and asymmetric. The symmetric one gives rise to a perfect copy of the initial NPC; this is also called self-renewing division. The asymmetric one gives rise to a daughter cell with limited differentiation potential. Depending on the growth and transcription factor NPC will differentiate into neurons or glial lineage.

The presence of NPC in the adult brain and their ability to self-renew deny the old belief of the neuronal tissue incapacity to regenerate.

NPC derived from iPSC is a cost-effective way to develop a good in vitro model for neurodegenerative disease as Parkinson, Huntington, or multiple sclerosis. This kind of model are helpful for fundamental research and an excellent tool for drug discovery. NPC derived from iPSC are also studied for cell therapy for neurodegenerative disease and stroke.

References:
[1] Martínez-Cerdeño Verónica, Noctor Stephen C,“Neural Progenitor Cell Terminology”, from Frontiers in Neuroanatomy 2018, 12:104.